Treatment sequencing involves the careful planning of the order in which therapies are
administered to patients to maximize therapeutic benefits and minimize adverse effects. This
process requires a deep understanding of disease progression, drug interactions, and individual
patient responses. However, the challenges in treatment sequencing are significant. It often
involves complex decision-making and sophisticated modeling to predict the most effective sequence
of interventions. Health Technology Assessment (HTA) plays a crucial role in this process by
evaluating the clinical and economic impacts of different sequencing strategies. Demonstrating the
value of optimal treatment sequences can be difficult, as the benefits often manifest over long
periods, requiring extensive data and advanced analytics to show improved patient outcomes and
cost-effectiveness.